DETAILS, FICTION AND CX-5461

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in significant-grade serous ovarian most cancersThese knowledge and preclinical efficacy reports provided a strong rationale to evaluate CX-5461 being a G4 stabilizer in HR-deficient good tumors. Non-scientific facts, the doubtless avoidable phototoxicity, and The short

Entirely, our info provide proof for your potential of combining CX-5461 and PARPi for strengthening the therapy of HR-deficient HGSOC. We show that CX-5461 boosts the synthetic lethal conversation of PARPi with HRD and clearly present that CX-5461 has a distinct mechanism of action to PARPi. Importantly, we characterised BRCA-mutated and MYC targe